Small molecules in spit may help diagnose concussions: study

first_imgWashington, Nov 25 (PTI) Tiny microRNA molecules in saliva may help diagnose and predict the duration of concussions in children, according to a study.Concussions usually occur after a blow to the head – for example, during sports or a car accident. They can result in such symptoms as headache, nausea, confusion, amnesia or lack of consciousness.Researchers measured the levels of microRNAs – tiny snippets of non coding RNA – in the saliva of concussion patients.They found that the presence of certain microRNAs in saliva was able to better identify concussions and more accurately predict the length of concussion symptoms than relying solely on patient surveys.Steven Hicks from the Pennsylvania State University in the US said the findings, published in the journal JAMA Pediatrics, could result in a more fact-based way to diagnose and treat concussion patients.”Theres been a big push recently to find more objective markers that a concussion has occurred, instead of relying simply on patient surveys,” Hicks said.”Previous research has focused on proteins, but this approach is limited because proteins have a hard time crossing the blood-brain barrier. Whats novel about this study is we looked at microRNAs instead of proteins, and we decided to look in saliva rather than blood,” he said.While most concussions clear up within two weeks, about one-third of patients will experience symptoms longer.Patients are usually advised to rest and stay away from such physical activity as sports or gym class until their symptoms subside.Hicks said that while it is important to give the brain enough time to heal, it is difficult to accurately predict how long patients should rest.advertisementThe researchers followed 52 concussion patients between the ages of 7 and 21 for the study.Each participant was evaluated using the Sport Concussion Assessment Tool (SCAT-3) – a common tool that doctors use to inventory concussion symptoms and severity – within two weeks of their injury.The researchers also asked the patients parents for their observations about their childrens symptoms.In the study, they also collected saliva from each participant and analysed for levels of different microRNAs.They then compared the microRNA profiles to the patients symptoms at both the initial and follow-up assessments.The researchers isolated five microRNAs that could accurately identify the participants who would experience prolonged symptoms.These microRNAs could correctly identify if a participant would have prolonged symptoms or not.”The microRNAs were able to predict whether symptoms would last beyond four weeks with about 85 percent accuracy,” Hicks said.”In comparison, using the SCAT-3 report of symptoms alone is about 64 per cent accurate. If you just go off the parents report of symptoms, it goes down to the mid-50s. In this pilot study, these molecular signatures are outperforming survey tools,” he said. PTI SNE SNElast_img read more

India thoroughly deserved to win, we did not take our chances: Tim Paine

first_imgIndia registered a thrilling 31-run victory over Australia in the opening Test of the four-match series at the Adelaide Oval on Monday. This was India’s first win in an opening Test of an Australian tour and their first win in Australia since 2008.Chasing a record 323 for a win, Australia were all out 291 in the extended second session on the final day thanks to a brilliant bowling performance by India. Pacers Jasprit Bumrah, Mohammed Shami and spinner Ravichandran Ashwin all picked three wickets each to hand India a famous win at the Adelaide Oval.Australia’s top and middle order struggled against the India bowlers but the lower-order, even the final wicket, kept the home team in the game with their valiant effort.Ashwin took the final wicket of Josh Hazlewood for 13 to complete India’s historic victory.Here’s the moment India sealed victory in another memorable Adelaide Test! #AUSvIND | @bet365_aus pic.twitter.com/8UU2DGdT9Pcricket.com.au (@cricketcomau) December 10, 2018Aussie skipper Tim Paine was gracious in defeat and praised the lower-order batsmen for putting up a “fight”.”It’s pretty shattering really. Proud of the fight from the lower order. A well-deserved win for India. We thought we could win, no doubt about that, but our batters couldn’t bat for long enough with our tail.”We saw how the pitch is playing and told ourselves we are gonna dig deep, but unfortunately, myself, Travis [Head] and Shaun [Marsh] couldn’t bat long as long as we should have,” Paine said at the post match presentation ceremony.advertisementPaine was a also full of praise for Cheteshwar Pujara, who hit 123 and 71 in the Test and was named the player of the match.”That’s [Pujara’s innings] the difference between the two sides. Really hard to get him (Pujara) out,” Paine said.Paine is hopeful of Australia bouncing back in the series.”We gotta cope with the belief that we can win this Test series, we just need someone in our top six to go big. My finger is fine,” he said.The second Test of the series will be played in Perth at the new stadium from December 14.Also Read | Virat Kohli sets sights on series triumph after historic Adelaide victorylast_img read more